Friday, October 10, 2008

SAMe and Depression

S-adenosyl-Methionine (SAMe)- A natural amino acid anti-depressant that is part of the homocysteine metabolism pathway and serves the role of “methylating” neurotransmitters. As
A very great natural anti-depressant is SAMe. This should NOT be used by those with bi-polar as it has been shown to cause manic outbreaks.

How does SAMe work?

SAMe converts to S-adenosyl-homocysteine it donates “methyl” groups (CH3) to the nervous system so that it can effectively produce neurotransmitters such as serotonin, dopamine, and catecholamines that make us feel GOOD and HAPPY. This natural anti-depressant is also a great detoxifying agent for the body as it activates phase II detoxification pathways in the body.

SAMe for Detox

If you are recovering from alcoholism or drug abuse this may be the better choice of natural anti-depressants, however it should not be used by those that suffer from bipolar because of it’s ability to increase catecholamines and may trigger a manic episode. I would stick with St. John’s wort or 5-HTP for those susceptible to manic or hypomanic episodes. Do NOT combine with prescription drugs. Typical dose of SAMe is 50 mg once to twice daily. Always take SAMe with magnesium for optimal methylation of neurotransmitters, and a multi-vitamin as the B-vitamins folic acid, B-6, and B-12 are necessary for preventing homocysteinemia, a potential consequence of consuming elevated levels of SAMe. Homocysteine is correlated with cardiovascular damage and B-vitamins will ensure it’s conversion to an inert substance.

A natural amino acid anti-depressant that is part of the homocysteine metabolism pathway and serves the role of “methylating” neurotransmitters. As SAMe converts to S-adenosyl-homocysteine it donates “methyl” groups (CH3) to the nervous system so that it can effectively produce neurotransmitters such as serotonin, dopamine, and catecholamines that make us feel GOOD and HAPPY. This natural anti-depressant is also a great detoxifying agent for the body as it activates phase II detoxification pathways in the body.

If you are recovering from alcoholism or drug abuse this may be the better choice of natural anti-depressants, however it should not be used by those that suffer from bipolar because of it’s ability to increase catecholamines and may trigger a manic episode. I would stick with St. John’s wort or 5-HTP for those susceptible to manic or hypomanic episodes. Do NOT combine with prescription drugs. Typical dose of SAMe is 50 mg once to twice daily. Always take SAMe with magnesium for optimal methylation of neurotransmitters, and a multi-vitamin as the B-vitamins folic acid, B-6, and B-12 are necessary for preventing homocysteinemia, a potential consequence of consuming elevated levels of SAMe. Homocysteine is correlated with cardiovascular damage and B-vitamins will ensure it’s conversion to an inert substance.

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DISCLAIMER:

This website is intended for educational purposes only. Read our full disclaimer. Always work with your physician for proper care and supervision. I strictly advise AGAINST combining herbs or natural therapies (aside from vitamins, minerals, or fish oil) with any form of anti-depressants. Although it is occasionally done, most naturopathic physicians, MD’s, and psychiatrists agree that until we have research demonstrating efficacy and safety herbs and natural anti-depressants with similar mechanisms to prescription drugs should not be simultaneously used. Also, although these medicines are “natural” they are still medicines. Please do not choose to discontinue your natural medicines without the advice of your physician, someone should be overseeing your care. Depression is complicated to sort out. Please do not try to do it alone. Someone needs to be documenting your mood fluctuations as well as when you start and stop specific therapies. Never make any changes to your health without first consulting with your physician. Have your physician check for drug interactions, and always be cautious when combining natural medicines and drugs for depression as the life threatening condition "Serotonin Syndrome" may occur. Work directly with a physician in regards to your bi-polar or depression.