Friday, October 10, 2008

5-HTP and Depression

Now most studies have been done on tryptophan, but because of past contamination issues it is tough to get your hands on tryptophan except through diet. 5-Hydroxy Tryptophan is just the new and improved tryptophan, and is a better therapeutic agent in my opinion because it is a biochemical step ahead of tryptophan in the production of serotonin, passing the “rate limiting step” that tryptophan fails to do. This means that 5-HTP can only feed forward in to serotonin and not go backwards in to something else.

With that being said this medicine can be a bit expensive, but is certainly worth a try! Do NOT combine this natural anti-depressant with prescription anti-depressants. I typically prescribe about 250 mg of 5-HTP on an empty stomach once or twice daily. This is pretty mega considering that most capsules start at 50mg, but the 200mg to 300mg range is what appears to work best.

5-HTP is also beneficial for insomnia, pain syndromes, schizophrenia, anorexia and bulimia, PMS, and migraine headaches. Excess tryptophan in the body is converted to serotonin (makes us happy) and melatonin (makes us sleepy). So if you have depression with insomnia this should work well for you.

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DISCLAIMER:

This website is intended for educational purposes only. Read our full disclaimer. Always work with your physician for proper care and supervision. I strictly advise AGAINST combining herbs or natural therapies (aside from vitamins, minerals, or fish oil) with any form of anti-depressants. Although it is occasionally done, most naturopathic physicians, MD’s, and psychiatrists agree that until we have research demonstrating efficacy and safety herbs and natural anti-depressants with similar mechanisms to prescription drugs should not be simultaneously used. Also, although these medicines are “natural” they are still medicines. Please do not choose to discontinue your natural medicines without the advice of your physician, someone should be overseeing your care. Depression is complicated to sort out. Please do not try to do it alone. Someone needs to be documenting your mood fluctuations as well as when you start and stop specific therapies. Never make any changes to your health without first consulting with your physician. Have your physician check for drug interactions, and always be cautious when combining natural medicines and drugs for depression as the life threatening condition "Serotonin Syndrome" may occur. Work directly with a physician in regards to your bi-polar or depression.